Runx3 Regulates Integrin
نویسندگان
چکیده
منابع مشابه
Runx3 Regulates Integrin E/CD103 and CD4 Expression during Development of CD4 /CD8 T Cells
During thymic T cell development, immature CD4 CD8 double-positive (DP) thymocytes develop either into CD4 CD8 Th cells or CD4 CD8 CTLs. Differentially expressed primary factors inducing the fate of these cell types are still poorly described. The transcription factor Runx3/AML-2 Runx, rust dominant factor; AML, acute myeloid leukemia is expressed specifically during the development of CD8 sing...
متن کاملRunx3 regulates mouse TGF-beta-mediated dendritic cell function and its absence results in airway inflammation.
Runx3 transcription factor regulates cell lineage decisions in thymopoiesis and neurogenesis. Here we report that Runx3 knockout (KO) mice develop spontaneous eosinophilic lung inflammation associated with airway remodeling and mucus hypersecretion. Runx3 is specifically expressed in mature dendritic cells (DC) and mediates their response to TGF-beta. In the absence of Runx3, DC become insensit...
متن کاملRunx3 negatively regulates Osterix expression in dental pulp cells.
Osterix, a zinc-finger-containing transcription factor, is required for osteoblast differentiation and bone formation. Osterix is also expressed in dental mesenchymal cells of the tooth germ. However, transcriptional regulation by Osterix in tooth development is not clear. Genetic studies in osteogenesis place Osterix downstream of Runx2 (Runt-related 2). The expression of Osterix in odontoblas...
متن کاملRunx2 and Runx3 are essential for chondrocyte maturation, and Runx2 regulates limb growth through induction of Indian hedgehog.
The differentiation of mesenchymal cells into chondrocytes and chondrocyte proliferation and maturation are fundamental steps in skeletal development. Runx2 is essential for osteoblast differentiation and is involved in chondrocyte maturation. Although chondrocyte maturation is delayed in Runx2-deficient (Runx2(-/-)) mice, terminal differentiation of chondrocytes does occur, indicating that add...
متن کاملGroucho/transducin-like Enhancer-of-split (TLE)-dependent and -independent transcriptional regulation by Runx3.
Regulation of gene expression by tissue-specific transcription factors involves both turning on and turning off transcription of target genes. Runx3, a runt-domain transcription factor, regulates cell-intrinsic functions by activating and repressing gene expression in sensory neurons, dendritic cells (DC), and T cells. To investigate the mechanism of Runx3-mediated repression in an in vivo cont...
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تاریخ انتشار 2005